Category: jbogmryd

Tamiflu may pose risk of mental side effects

first_imgNov 14, 2006 (CIDRAP News) – Mainly on the basis of reports from Japan, drug manufacturer Roche and US regulators are warning that influenza patients treated with oseltamivir (Tamiflu) may have an increased risk of self-injury and delirium.”People with the flu, particularly children, may be at increased risk of self-injury and confusion shortly after taking Tamiflu and should be closely monitored for signs of unusual behavior,” says a warning that Roche has added to its official product information, according to a company letter posted on the Food and Drug Administration (FDA) Web site.Oseltamivir, a neuraminidase inhibitor, is used both to prevent and to treat flu and is regarded as the best available drug for dealing with a potential pandemic strain of flu. The United States and many other countries are stockpiling it because of the pandemic threat.The warning follows an FDA review of 103 reports of neuropsychiatric adverse events associated with oseltamivir use between Aug 29, 2005, and Jul 6, 2006, of which 95 came from Japan. That compares with 126 such adverse events reported between 1999 and August 2005. About two thirds of the problems were in children and youth (younger than 17 years).A report by the FDA’s Center for Drug Evaluation and Research says the adverse events included three fatal falls—one in a 14-year-old boy who apparently fell to his death from a condominium balcony and two in men. Most of the events (60 of 103) were described as delirium with disturbed behavior. Other problems included “suicidal events,” panic attacks, delusions, convulsions, depressed consciousness, and loss of consciousness.The FDA and Roche both say the contribution of the drug to the adverse events is not known. The FDA report says influenza by itself can lead to neuropsychiatric disorders, but many of the problems reported, especially delirium and suicide attempts, were not typical of those associated with flu alone.Citing factors that seem to implicate oseltamivir in the events, the FDA said most of the problems occurred within a day after the start of treatment, and in many cases the physician suspected the drug was the cause. In addition, many of the patients recovered quickly after they stopped taking oseltamivir.”It is still unclear whether these neuropsychiatric events are drug-related only, disease manifestations alone, or a combination” of the two, the report states.The analysis notes that oseltamivir is used much more widely in Japan, with 24.5 million prescriptions from 2001 thorugh 2005, than in the United States, with 6.5 million prescriptions in the same period. In Japan the product information already includes a warning about possible psychoneurological problems.The FDA report expresses concern that if oseltamivir use in the United States increases to the levels seen in Japan, the number of adverse events will increase as well. “Therefore, it would be prudent to update the U.S. labeling to be similar in scope with the current Japanese labeling,” it says.The Japanese origin of most of the adverse event reports might suggest that the problems are related to genetic characteristics common in Japan, the FDA analysis says. But given the much greater use of the drug in Japan and the possibility of different surveillance practices there, the lack of cases reported in the United States doesn’t constitute good evidence for that hypothesis, it states.The FDA analysis was prepared for the agency’s Pediatric Advisory Committee, which is scheduled to meet Nov 16.The latest developments come about a year after that committee concluded that 12 deaths in Japanese children who had been taking oseltamivir were not related to the drug. The FDA said then that the deaths seemed to be part of a wave of flu-related encephalitis and encephalopathy cases in Japanese children that began in the mid-1990s, before the drug was approved. But the committee asked the FDA to continue monitoring the situation and report again in a year.See also:FDA advice about potential neuropsychiatric side effects of Tamifluhttp://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm150758.htmRoche letter about possible riskshttp://www.fda.gov/downloads/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/UCM153422.pdfFDA staff analysis of adverse-event reports concerning TamifluNov 18, 2005, CIDRAP News story “FDA panel: Children’s deaths unrelated to Tamiflu”last_img read more

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Viola “Toby” Brooks

first_imgViola “Toby” Brooks, 94, of Lawrenceburg, Indiana, formerly of Aurora, IN and Connersville, IN, passed away Thursday, March 3, 2016.She was born Sunday, June 19, 1921 in Campbell County Kentucky, daughter of the late Oliver Webster and the late Rosa Bachman Webster.Viola enjoyed being a homemaker, and loved antiques.She enjoyed home decorating and camping in her younger years. Viola enjoyed having yard sales, and browsing yard sales.Surviving are nieces and nephews, Jackie Steele Wurth of Independence, Ky, Linda (David) Pitstick, Lonnie (Sally) Steele, Merle (Sarah) Steele, Robert Steele, Donna (Clay) Montang.She was preceded in death by her husband, James Leslie Brooks; sisters, Jessie Yelton, and Helen Steele; and brothers, Edwin Webster, and Albert Webster.Graveside Services will be held at 11:00 am Friday, March 18, 2016 at River View Cemetery.Contributions may be made to the Alzheimer’s Association or American Cancer Society. Please call the Rullman Hunger Funeral Home office at (812) 926-1450 and we will notify the family of your donation with a card.last_img read more

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One killed in Madison crash Sunday

first_imgMadison, In. — Indiana State Police say a one person was killed and four others injured in a Sunday crash at 6 p.m. in the 400 Block of Clifty Drive in Madison.Investigators from the Indiana State Police-Versailles Crash Reconstruction Team determined a vehicle driven by Clarence P. Wiseman, age 72, Deputy, Indiana pulled northbound onto Clifty Drive from a business on the south side of the roadway.  Wiseman’s vehicle entered the roadway into the path of a westbound car driven by Donald W. Abbott Jr., age 37, Lexington, Indiana.  The front driver’s side of Abbott’s vehicle struck the front passenger side of Wiseman’s vehicle.As a result of the collision, a passenger in Wiseman’s vehicle, D. Keith Hazelwood, 59, of Madison, sustained fatal injuries.  Wiseman sustained serious injuries.  He was flown to the University of Louisville Hospital for treatment.Abbott, along with his wife Christy L. Abbott, age 40, and their son Bret Abbott, age 10, sustained minor injuries.  They were all transported to King’s Daughters’ Hospital in Madison, Indiana for treatment.The initial investigation revealed that neither Wiseman nor Hazelwood were properly restrained in the vehicle at the time of the crash.Alcohol and drugs are not suspected to be factors in the crash although toxicology results on both drivers are pending.The investigation is ongoing.last_img read more

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Sagna signs for City

first_img The 31-year-old will join the Barclays Premier League champions from Arsenal following the World Cup in Brazil on a three-year deal. Sagna, who made 284 appearances for the Gunners after signing from Auxerre in the summer of 2007, is in Didier Deschamps’ France squad, who will face Switzerland, Ecuador and Honduras in Group E. Manchester City have announced the signing of France and Arsenal defender Bacary Sagna. City say the defender will wear the vacant number three shirt at the Etihad Stadium, the same number he wore for Arsenal. Sagna chose to leave the Emirates Stadium on a free transfer having turned down the offer of a new contract. The Gunners, however, sent their best wishes to the player. “Bacary Sagna has agreed to join Manchester City after his contract with Arsenal expires on June 30,” said an Arsenal statement. “An integral part of Arsenal’s defence over the past seven seasons, the France international brought his time with the Gunners to a fitting close last month when he helped the team win the FA Cup in his final match. “Everyone at Arsenal Football Club would like to thank Bacary for his fantastic contribution, and wish him all the best for the future.” Sagna will contest the right-back slot with established first-choice Pablo Zabaleta, widely considered to be the most consistent Premier League performer in that position for the last two years, and the Frenchman’s arrival almost certainly signals the end of Micah Richards’ career at the club. City now have considerable strength in the full-back positions with Zabaleta and Sagna on the right and Gael Clichy and Aleksandar Kolarov, who signed a new three-year contract on Thursday, on the left. center_img Press Associationlast_img read more

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CV doesn’t matter to me; prove it on the pitch! – Golden Jaguars head coach

first_img… Brazilian hints new policy to expose local playersNEW head coach of the country’s senior national men’s football team, Márcio Máximo, has made it clear that big names or playing in a big league wouldn’t impress him. He told Chronicle Sport that players have to prove their worth in order to break into the Golden Jaguars team. Following Guyana’s 4-0 defeat to Reggae Boyz on Monday night at the National Track and Field Centre, in the team’s latest match in the CONCACAF Nations League, Máximo was responding to Chronicle Sport’s question as to why Terrel Ondaan, who plays with Grenoble Foot 38 France’s Ligue 2, didn’t find favour in his lineup against Jamaica, even as a substitute.“It’s our new policy to give more chances to local players. I don’t talk about players, I talk about a team. Don’t ask me about a player because I never talk; I talk inside the changing room,” Máximo boldly expressed.Terell Ondaan in action for Guyana during the 2019 CONCACAF Gold CupMany football fans, especially those knowing the ability of the 25-year-old forward who was born in the Netherlands and broke onto the scenes following his youth career at Ajax and Alkmaar Zaanstreek (AZ) football clubs, were left scratching their heads after Ondaan, who made 78 appearances for another top Dutch club, Willem II, was left off of the starting line-ups for both of the Golden Jaguars Nations League encounters.In fact, Ondaan lost his spot to Kelsey Benjamin, a nifty 20-year-old who this season moved to Trinidad and Tobago to play in the Islands’ Professional league with Morvant Caledonia United – a team owned and managed by former Golden Jaguars coach Jamaal Shabazz.Ondaan has found the net once this season in the French league, and has been a regular starter for his side.“Players should prove themselves on the pitch, not with talk or their Curriculum Vitae,” Máximo expressed, while adding that CV doesn’t prove anything. You have to prove it on the pitch. Shelly (Sheldon Holder) was in better condition, that’s why he’s playing. But I don’t like talking about players, I talk about a team.”Máximo’s comments might seem a bit farfetched, given the fact that he could not have seen the players in action, since he only took over after coach Michael Johnson departed in mid-August.Máximo also had only three days in camp with the players in Curacao prior to their game against Aruba where they went on to win 1-0, thanks to a 22nd minute goal from Sheldon Holder.Ondaan, the former Netherlands U-18 and U-21 player, moved from Telstar in the Dutch League to France just upon his return home from the Gold Cup where he made one start (against Panama), winning a penalty that was converted by Neil Danns.Matthew Briggs, Neil Danns, Samuel Cox, Sheldon Holder, Kelsey Benjamin, Liam Gordon, Keanu Marsh-Brown, Akel Clarke and Stephen Duke-McKenna were the overseas-based players on the team for the first two Nations League games.Meanwhile, specifically addressing Guyana’s loss to Jamaica, Máximo recounted, “I think we paid the price in the first half … in the second half we fixed our mistakes, because we went to the changing room and we did our tactical adjustments and we became better. It’s a good lesson for us because Jamaica are a good team.“Of course we are as well, but in the meantime we have a long way to go. I’m not a magician, we’re going to take lessons from each game and for the next game we’re going to get better.”last_img read more

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Pride declared champions after CWI aborts first class championship

first_imgBRIDGETOWN, Barbados (CMC) – Cricket West Indies (CWI) has aborted the remaining two rounds of the domestic first-class championship and declared leaders Barbados Pride champions of the 2020 season.The decision was taken following a board of directors’ teleconference on Tuesday, where the governing body also moved to scrap the Regional Under-15s Boys Championship and the West Indies Under-15s tour to England scheduled to take place this summer.CWI had last week suspended the first-class championship following the eighth round of matches, due to the outbreak of the coronavirus pandemic in the Caribbean, and also postponed the Under-15 Boys Championship, the Women’s Super50 Cup and the inaugural Regional Under-19s Women’s T20 Championship.Despite the cancellations, CWI hopes to salvage the Women’s Super50 Cup and the Regional Under-19s Women’s T20 Championship and have postponed them until later in the year.“All around the sporting world we are faced with the challenges presented by the COVID-19 pandemic,” CWI chief executive Johnny Grave said.“Cricket, cricketers and all our stakeholders involved in the game have been affected at various levels and we must continue to work together and act responsibly in containing the spread of the virus.”He continued: “Ten days ago, we suspended our tournaments and camps for 30 days and now we have extended that suspension until the end of May as well as reluctantly cancelled some tournaments and tours in their entirety.“We will continue to monitor and assess the situation and make further decisions and announcements in due course.”When the first-class championship was halted, Pride topped the standings with 134.8 points, well ahead of second-placed Trinidad and Tobago Red Force second on 94.6 points.And although their lead, though significant, was not yet unassailable, Grave said the decision among directors had been “unanimous” to award Pride the Headley/Weekes Trophy.“The major discussion point that came from the board of directors as a unanimous decision for us to curtail the last two rounds of the first class season and announce Barbados Pride as the winners of the West Indies championship and award them the Headley/Weekes Trophy,” the Englishman said.“Barbados are significant leaders after eight rounds … and though mathematically Trinidad, Guyana and Jamaica could overtake them if they’d won the final two games, Barbados Pride would’ve almost certainly picked up enough bonus points even if they’d lost their final two games and still be winners.”He continued: “Notwithstanding the maths of the situation the board members were unanimous that if the season was to end now, (that we) would announce Barbados as the winners and Trinidad and Tobago Red Force as the runners-up, so that’s the situation with the West Indies championship.”Ironically, Pride started the campaign with a shock three-wicket defeat to Windward Islands Volcanoes before recovering to go on a five-game winning streak to storm to the top of the standings.Five-time defending champions, Guyana Jaguars, who had dominated the tournament since the inception of the professional era, finished joint-third with Jamaica Scorpions on 91.8 points.Volcanoes ended in fifth spot on 78 points with Leeward Islands Hurricanes last on 52.8 points.last_img read more

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Vucevic earns Pac-10 Player of the Week

first_imgFollowing resounding victories over No. 10 Arizona and Arizona State, USC junior forward Nikola Vucevic was named Pac-10 men’s basketball Player of the Week for the week of Feb. 21-27.Inside presence · Junior Nikola Vucevic has been a double-double machine for the USC men’s basketball team the entire season, averaging 17.5 points and 10.3 rebounds. – Carlo Acenas | Daily Trojan Vucevic’s strong play as of late has powered the Trojans to four straight wins, increasing their chances of earning an NCAA tournament at-large bid.In the Trojans’ 65-57 upset win over No. 10 Arizona, which snapped the Wildcats’ eight-game winning streak, Vucevic had a game-high of 25 points and 12 rebounds.But it was his 17-point contribution in the second half that helped the Trojans bounce back from a late four-point deficit to win the game.In the Trojans’ 62-46 win over Arizona State on Saturday, Vucevic tallied 20 points and 10 rebounds, finishing the week with per game averages of 22 points and 11 rebounds.He notched his 18th double-double of the season, and sixth straight overall.Vucevic’s father, Borislav, was in attendance for both games at the Galen Center — it was the first time he was able to watch his son play in person while at USC.This is Vucevic’s first career Pac-10 Player of the Week honor and the 33rd Trojan basketball player to receive the award for USC all-time.It is the second time this season a Trojan has won Pac-10 Player of the Week, as junior guard Jio Fontan earned the award for the week of Dec. 20-26.Vucevic and the Trojans will finish off their season on the road, going head-to-head with Washington State on Thursday and Washington on Saturday.last_img read more

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3 takeaways from Syracuse’s 69-61 win over Pittsburgh

first_img Facebook Twitter Google+ Published on January 25, 2020 at 2:16 pm Contact Michael: mmcclear@syr.edu | @MikeJMcCleary Syracuse (13-7, 6-3 Atlantic Coast) held on to its lead to beat Pittsburgh (13-7, 4-5), 67-61, on Saturday afternoon. The Orange built a 20-point lead five minutes into the game, but Pitt fought back in the second half. The Orange’s early lead, while it dwindled, was enough to stave off the Panthers.Here are three takeaways from Syracuse’s fifth-straight victory: Timing is keySyracuse blocked five shots in eight minutes and five of the Panthers first 11 shot attempts. Elijah Hughes, who typically times his jumps well on shot-contests, blocked three shots over that same stretch and finished the game with six blocks. When the Orange started to lose control of the game, however, it was because of Pitt’s ability to get shots off inside and get fouled. The Panthers offensive ineffectiveness was clear all game, but the most glaring issues showed when SU’s 2-3 zone pushed it beyond the free-throw line. Side-to-side ball movement around the perimeter, without willing shooters, led to multiple shot-clock violations as the Panthers tried to figure out effective ways to get the ball to its bigs down low.AdvertisementThis is placeholder textBuddy BucketsThough Hughes didn’t score until the second half and the rest of the Orange struggled to find its range all game, Buddy Boeheim bounced back from an 0-for-5 performance against Notre Dame and strong-armed a first half run that established SU’s cushion. Buddy scored 18 points in the first half and hit a slump-busting 3-pointer in the second frame at a point of the game when Hughes and Joe Girard III had only combined for seven points.The Orange’s scoring came from few others in the game, but they happened to be playing in a game where strong play on offense wasn’t very necessary.Home sweet home?Syracuse started its four-game winning streak largely by playing its best offense of the season. It burst in overtime against Virginia’s dynamic defense, played ahead of Virginia Tech, dominated Boston College and gathered a large enough offensive cushion to stave off a Notre Dame comeback. Three of the wins, and the offensive explosions, have come in road games. In the Orange’s return to the Dome, its shooting fell off significantly.In front of the largest on-campus crowd in college basketball this season, SU hit just five of its 21 3-pointers and shot 43.6% from the field in the game. Girard had just two points until a 3-pointer with under seven minutes in the game, and Hughes finished the game with 10 points. Commentslast_img read more

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Algeria Beat Cote d’Ivoire in Shoot out to Set up S’final…

first_imgCote d’Ivoire forced extra time after Aston Villa forward Jonathan Kodjia’s low finish but, after no further goals, the tie was decided by penalties.Algeria, seeking a first AFCON triumph since 1990 when they hosted and won will face the same Nigeria they defeated to win their lone title to date.Cote d’Ivoire had gone close to scoring when the game was goalless, Rais M’Bolhi pushing Max Gradel’s attempt on to the post.Crystal Palace forward Wilfried Zaha went into the quarter-final looking to increase his two-goal tally at the tournament.However, the Ivorian player was booked and fortunate to escape a red card after a confrontation with Ramy Bensebaini.Zaha and Algeria’s Riyad Mahrez had been replaced by the end of the 120 minutes and did not take part in the penalty shootout.Former Manchester City player Wilfried Bony had already had a penalty saved when team-mate Serey Die hit the post, earning Algeria victory.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram Algeria defeated Elephants of Cote d’Ivoire 4-3 in penalty shoot out last night after regulation and extra time ended 1-1. The Desert Foxes are now primed to face three-time champions Nigeria in one of the semi finals of the 2019 Africa Cup of Nations in Cairo, Egypt.Algeria took the lead through ex-West Ham winger Sofiane Feghouli’s side-foot finish before they missed a penalty.Baghdad Bounedjah, who had been fouled by keeper Sylvain Gbohouo, hit the bar. Cote d’Ivoire’s Jonathan Kodja (second right) is challenged for ball control by Algerian defender Aissa Mandi during their quarter final clash in Cairo International Stadium last nightlast_img read more

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Coach Kwesi Appiah endorsed as UniBank brand ambassador

first_imgBlack Stars coach Kwesi Appiah has been endorsed as the brand ambassador of one of Ghana’s leading Bank and the official bank sponsors of the Black Stars UniBank.Appiah, who has qualified the Black Stars to a third-straight World Cup appearance, has been the subject of talks as the first indigenous coach to achieve this feat.The Chief  Operating Officer, Dr Kwabena Duffuor Jnr of the  Bank,  speaking at a short honoring ceremony held by his outfit  last month as the Official Bank of the Black Stars.Coach Appiah also promised to carry the brand to the highest level in Brazil by making sure the Black Stars make a final four finish.“We are proud of successes and will continue to support him to lead the Black Stars to the 2014 World Cup in Brazil. Doctor Kwabena Duffuor Jnr. said“Let us re-direct our energies and resources towards ensuring that we seal our semi final target in the 2014 FIFA World Cup in Brazil. The technical team led by Coach Kwesi Appiah, the players and management of the Black Stars need your support and prayers in achieving this target.” Doctor Kwabena Duffuor Jnr. added The Black Stars have been drawn in Group G alongside Germany, Portugal and  the United States of America.last_img read more

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